The creative underpinnings of “Sticky Settings” are informed by our shared fascination with the layers of translation involved in representations of molecular biology that are mediated by technology and computation. In software interfaces, “sticky settings” is a phrase used to describe“remembered” user settings. “Sticky” is also a term used to describe certain molecular interactions in his computer-generated models. In biology, evidence has emerged for gene bookmarking suggesting mechanisms of epigenetic memory or“stickiness” in DNA. We are exploring how sensations of tactility can be evoked with both physical and digital representations of biology. Our collaborative artworks attempt to repurpose the “GUI” interfaces with which we confront “gooey” biological materialities in the lab and reframe their implications in our everyday lives.